Science
Our formulations are grounded in peer-reviewed science. Below are key studies on melatonin and its role in sleep, circadian health, immunity and overall wellness — the research that informs our Malonin™ Spray and broader product line.
Poza JJ, Pujol M, Ortega-Albás JJ, Romero O — Insomnia Study Group, Spanish Sleep Society
Neurología (Elsevier)
Comprehensive review of melatonin physiology, pharmacology and clinical use in primary insomnia, comorbid insomnia and circadian rhythm sleep-wake disorders. Confirms melatonin's role as the master regulator of the sleep-wake cycle and outlines effective dosing strategies for adults.
Sarisozen B, Aslan FS, Akyuz E
Melatonin Research (Vol 6, Issue 3)
Recent review demonstrating melatonin's regulatory role in circadian rhythm, sleep-wake balance, metabolic health, reproductive hormones and immune function. Highlights melatonin's protective effect on disrupted rhythms across multiple pathological conditions.
Costello RB, Lentino CV, Boyd CC, et al.
Nutrition Journal, 13:106
Systematic review of 35 high-quality randomised controlled trials. Supports melatonin for preventing jet-lag phase shifts, improving insomnia in healthy adults and people with a history of insomnia, and reducing time-to-sleep-onset.
Stanford SC, et al.
British Journal of Pharmacology
Authoritative pharmacology review covering melatonin's MT1/MT2 receptor mechanisms and emerging therapeutic potential beyond sleep — including antioxidant, anti-inflammatory, neuroprotective and oncostatic effects.
Erland LAE, Saxena PK
Journal of Clinical Sleep Medicine
Landmark analysis showing melatonin content in commercial supplements can vary from −83% to +478% of label claim, with unlisted serotonin contamination in many products. Underscores why pharmaceutical-grade manufacturing (as in Malonin™ Spray) matters.
Acuña-Castroviejo D, et al.
Journal of Pineal Research
Clinical trial protocol and evidence supporting melatonin as an adjuvant therapy in COVID-19 — leveraging its anti-inflammatory, antioxidant and immunomodulatory properties to reduce cytokine storm and improve outcomes.
Disclaimer: The research listed is provided for informational and educational purposes only. It does not constitute medical advice. Consult your healthcare professional before starting any supplement.
